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Table 5 Response to treatment (outcome)- related cluster statistics. Ward`s Euclidean method, χ2 test, p < 0.05. Abbreviations for respective responses to treatment are defined in Supplement Table 1

From: Treatment outcome clustering patterns correspond to discrete asthma phenotypes in children

Feature / No of patients Cluster 1 (N = 58) Cluster 2 (N = 87) Cluster 3 (N = 138) Cluster 4 (N = 64) p-value
  Good
N (%)
Moderate
N (%)
Poor
N (%)
Good
N (%)
Moderate
N (%)
Poor
N (%)
Good
N (%)
Moderate
N (%)
Poor
N (%)
Good
N (%)
Moderate
N (%)
Poor
N (%)
 
Resp FEV1
baseline to 1st control
17
(29.31)
27
(46.55)
14
(24.14)
8
(9.2)
45
(51.72)
34
(39.08)
75
(54.35)
49
(35.51)
14
(10.14)
19
(29.69)
24
(37.5)
21
(32.81)
 < 
0.001
Resp FENO baseline to 1st control 1
(1.72)
57
(98.28)
0
(0)
79
(90.8)
7
(8.05)
1
(1.15)
108
(78.26)
14
(10.14)
16
(11.59)
58
(90.62)
4
(6.25)
3
(3.12)
 < 
0.001
Resp CTRL baseline to 1st control 34
(58.62)
12
(20.69)
12
(20.69)
55
(63.22)
22
(25.29)
10
(11.49)
94
(68.12)
16
(11.59)
28
(20.29)
34
(53.12)
11
(17.19)
19
(29.69)
 < 
0.05
Resp MEF50 baseline to 1st control 18
(31.03)
22
(37.93)
18
(31.03)
5
(5.75)
43
(49.43)
39
(44.83)
75
(54.35)
43
(31.16)
20
(14.49)
20
(31.25)
22
(34.38)
22
(34.38)
 < 
0.001
Resp FEV1 1st to 2nd control 9
(15.52)
46
(79.31)
3
(5.17)
10
(11.49)
64
(73.56)
13
(14.94)
44
(31.88)
70
(50.72)
24
(17.39)
18
(28.12)
40
(62.5)
6
(9.38)
 < 
0.001
Resp FENO 1st to 2nd control 48
(82.76)
10
(17.24)
0
(0)
55
(63.22)
21
(24.14)
11
(12.64)
84
(60.87)
30
(21.74)
24
(17.39)
39
(60.94)
14
(21.88)
11
(17.19)
 < 
0.05
Resp CTRL 1st to 2nd control 52
(89.66)
2
(3.45)
4
(6.9)
59
(67.82)
11
(12.64)
17
(19.54)
118
(85.51)
4
(2.9)
16
(11.59)
46
(71.88)
6
(9.38)
12
(18.75)
 < 
0.01
Resp FEV1 2nd to 3rd control 3
(5.17)
45
(77.59)
10
(17.24)
11
(12.64)
73
(83.91)
3
(3.45)
21
(15.22)
89
(64.49)
28
(20.29)
4
(6.25)
42
(65.62)
18
(28.12)
 < 
0.001
Resp FENO 2nd to 3rd control 16
(27.59)
26
(44.83)
16
(27.59)
29
(33.33)
48
(55.17)
10
(11.49)
54
(39.13)
75
(54.35)
9
(6.52)
23
(35.94)
29
(45.31)
12
(18.75)
 < 
0.01
Resp CTRL 2nd to 3rd control 53
(91.38)
3
(5.17)
2
(3.45)
82
(94.25)
5
(5.75)
0
(0)
128
(92.75)
6
(4.35)
4
(2.9)
2
(3.12)
9
(14.06)
53
(82.81)
 < 
0.001
Resp MEF50 2nd to 3rd control 3
(5.17)
41
(70.69)
14
(24.14)
20
(22.99)
57
(65.52)
10
(11.49)
38
(27.54)
76
(55.07)
24
(17.39)
4
(6.25)
36
(56.25)
24
(37.5)
 < 
0.001
Resp FEV1 baseline to 2nd control 22
(37.93)
23
(39.66)
13
(22.41)
6
(6.9)
42
(48.28)
39
(44.83)
79
(57.25)
54
(39.13)
5
(3.62)
19
(29.69)
30
(46.88)
15
(23.44)
 < 
0.001
Resp FENO baseline to 2nd control 7
(12.07)
0
(0)
51
(87.93)
13
(14.94)
65
(74.71)
9
(10.34)
25
(18.12)
90
(65.22)
23
(16.67)
14
(21.88)
42
(65.62)
8
(12.5)
 < 
0.001
Resp CTRL baseline to 2nd control 50
(86.21)
6
(10.34)
2
(3.45)
61
(70.11)
16
(18.39)
10
(11.49)
120
(86.96)
10
(7.25)
8
(5.8)
42
(65.62)
10
(15.62)
12
(18.75)
 < 
0.01
Resp MEF50_diagn to 2nd control 17
(29.31)
27
(46.55)
14
(24.14)
3
(3.45)
36
(41.38)
48
(55.17)
74
(53.62)
60
(43.48)
4
(2.9)
14
(21.88)
35
(54.69)
15
(23.44)
 < 
0.001
Resp FEV1 baseline to 3rd control 19
(32.76)
20
(34.48)
19
(32.76)
8
(9.2)
49
(56.32)
30
(34.48)
71
(51.45)
62
(44.93)
5
(3.62)
8
(12.5)
39
(60.94)
17
(26.56)
 < 
0.001
Resp FENO baseline to 3rd control 12
(20.69)
25
(43.1)
21
(36.21)
15
(17.24)
56
(64.37)
16
(18.39)
34
(24.64)
86
(62.32)
18
(13.04)
10
(15.62)
37
(57.81)
17
(26.56)
 < 
0.01
Resp CTRL baseline to 3rd control 53
(91.38)
5
(8.62)
0
(0)
81
(93.1)
6
(6.9)
0
(0)
135
(97.83)
3
(2.17)
0
(0)
4
(6.25)
20
(31.25)
40
(62.5)
 < 
0.001
Resp MEF50 baseline to 3rd control 11
(18.97)
30
(51.72)
17
(29.31)
5
(5.75)
37
(42.53)
45
(51.72)
71
(51.45)
61
(44.2)
6
(4.35)
4
(6.25)
36
(56.25)
24
(37.5)
 < 
0.001