Table 5 Response to treatment (outcome)- related cluster statistics. Ward`s Euclidean method, χ2 test, p < 0.05. Abbreviations for respective responses to treatment are defined in Supplement Table 1

Resp FEV₁

baseline to 1^st control

17

(29.31)

27

(46.55)

14

(24.14)

8

(9.2)

45

(51.72)

34

(39.08)

75

(54.35)

49

(35.51)

14

(10.14)

19

(29.69)

24

(37.5)

21

(32.81)

Resp FENO baseline to 1^st control

1

(1.72)

57

(98.28)

0

(0)

79

(90.8)

7

(8.05)

1

(1.15)

108

(78.26)

14

(10.14)

16

(11.59)

58

(90.62)

4

(6.25)

3

(3.12)

Resp CTRL baseline to 1^st control

34

(58.62)

12

(20.69)

12

(20.69)

55

(63.22)

22

(25.29)

10

(11.49)

94

(68.12)

16

(11.59)

28

(20.29)

34

(53.12)

11

(17.19)

19

(29.69)

Resp MEF₅₀ baseline to 1^st control

18

(31.03)

22

(37.93)

18

(31.03)

5

(5.75)

43

(49.43)

39

(44.83)

75

(54.35)

43

(31.16)

20

(14.49)

20

(31.25)

22

(34.38)

22

(34.38)

Resp FEV₁ 1^st to 2^nd control

9

(15.52)

46

(79.31)

3

(5.17)

10

(11.49)

64

(73.56)

13

(14.94)

44

(31.88)

70

(50.72)

24

(17.39)

18

(28.12)

40

(62.5)

6

(9.38)

Resp FENO 1^st to 2^nd control

48

(82.76)

10

(17.24)

0

(0)

55

(63.22)

21

(24.14)

11

(12.64)

84

(60.87)

30

(21.74)

24

(17.39)

39

(60.94)

14

(21.88)

11

(17.19)

Resp CTRL 1^st to 2^nd control

52

(89.66)

2

(3.45)

4

(6.9)

59

(67.82)

11

(12.64)

17

(19.54)

118

(85.51)

4

(2.9)

16

(11.59)

46

(71.88)

6

(9.38)

12

(18.75)

Resp FEV₁ 2^nd to 3^rd control

3

(5.17)

45

(77.59)

10

(17.24)

11

(12.64)

73

(83.91)

3

(3.45)

21

(15.22)

89

(64.49)

28

(20.29)

4

(6.25)

42

(65.62)

18

(28.12)

Resp FENO 2^nd to 3^rd control

16

(27.59)

26

(44.83)

16

(27.59)

29

(33.33)

48

(55.17)

10

(11.49)

54

(39.13)

75

(54.35)

9

(6.52)

23

(35.94)

29

(45.31)

12

(18.75)

Resp CTRL 2^nd to 3^rd control

53

(91.38)

3

(5.17)

2

(3.45)

82

(94.25)

5

(5.75)

0

(0)

128

(92.75)

6

(4.35)

4

(2.9)

2

(3.12)

9

(14.06)

53

(82.81)

Resp MEF₅₀ 2^nd to 3^rd control

3

(5.17)

41

(70.69)

14

(24.14)

20

(22.99)

57

(65.52)

10

(11.49)

38

(27.54)

76

(55.07)

24

(17.39)

4

(6.25)

36

(56.25)

24

(37.5)

Resp FEV₁ baseline to 2^nd control

22

(37.93)

23

(39.66)

13

(22.41)

6

(6.9)

42

(48.28)

39

(44.83)

79

(57.25)

54

(39.13)

5

(3.62)

19

(29.69)

30

(46.88)

15

(23.44)

Resp FENO baseline to 2^nd control

7

(12.07)

0

(0)

51

(87.93)

13

(14.94)

65

(74.71)

9

(10.34)

25

(18.12)

90

(65.22)

23

(16.67)

14

(21.88)

42

(65.62)

8

(12.5)

Resp CTRL baseline to 2^nd control

50

(86.21)

6

(10.34)

2

(3.45)

61

(70.11)

16

(18.39)

10

(11.49)

120

(86.96)

10

(7.25)

8

(5.8)

42

(65.62)

10

(15.62)

12

(18.75)

Resp MEF₅₀_diagn to 2^nd control

17

(29.31)

27

(46.55)

14

(24.14)

3

(3.45)

36

(41.38)

48

(55.17)

74

(53.62)

60

(43.48)

4

(2.9)

14

(21.88)

35

(54.69)

15

(23.44)

Resp FEV₁ baseline to 3^rd control

19

(32.76)

20

(34.48)

19

(32.76)

8

(9.2)

49

(56.32)

30

(34.48)

71

(51.45)

62

(44.93)

5

(3.62)

8

(12.5)

39

(60.94)

17

(26.56)

Resp FENO baseline to 3^rd control

12

(20.69)

25

(43.1)

21

(36.21)

15

(17.24)

56

(64.37)

16

(18.39)

34

(24.64)

86

(62.32)

18

(13.04)

10

(15.62)

37

(57.81)

17

(26.56)

Resp CTRL baseline to 3^rd control

53

(91.38)

5

(8.62)

0

(0)

81

(93.1)

6

(6.9)

0

(0)

135

(97.83)

3

(2.17)

0

(0)

4

(6.25)

20

(31.25)

40

(62.5)

Resp MEF₅₀ baseline to 3^rd control

11

(18.97)

30

(51.72)

17

(29.31)

5

(5.75)

37

(42.53)

45

(51.72)

71

(51.45)

61

(44.2)

6

(4.35)

4

(6.25)

36

(56.25)

24

(37.5)