Fig. 3
From: Treatment outcome clustering patterns correspond to discrete asthma phenotypes in children
A schematic representation of the main characteristics of the 4 clusters identified in this study. Clusters 1 and 3 seem to have a more positive pattern of treatment outcomes and were characterized by more prominent atopic markers and a predominant allelic (A) effect for rs37973, a polymorphism in the GLCCI1 gene, and with a relatively later onset of disease. Clusters 2 and 4 had poorer treatment success patterns and were characterized by higher levels of airway and systemic inflammation and comorbidities, but varied in the type of inflammation (predominantly neutrophilic for cluster 4 and mixed-type for cluster 2) and platelet count (lowest for cluster 4). Cluster 2 was the only one with relatively earlier onset of asthma (5 years of age)