Table 2 Patient Medication Classes by Exacerbation Count Levels. Patients were assigned to oral corticosteroid and respiratory agent medication classes if they had at least one order or prescription for a medication corresponding to each class in 2011–2014 UPHS EHRs. For each category, N (%) for raw data are shown
Medication Class | Number of Exacerbations | P-Value | |||
|---|---|---|---|---|---|
0 | 1–2 | 3–4 | 5+ | ||
(N = 6042) | (N = 2639) | (N = 273) | (N = 114) | ||
Anticholinergic | 525 (8.69) | 862 (32.66) | 154 (56.41) | 95 (83.33) | < 1e-15 |
Anti-IgE | 20 (0.33) | 29 (1.1) | 12 (4.4) | 10 (8.77) | <1e-15 |
Epinephrine | 209 (3.46) | 120 (4.55) | 20 (7.33) | 16 (14.04) | 7.73e-9 |
ICS | 2583 (42.75) | 1307 (49.53) | 170 (62.27) | 72 (63.16) | < 1e-15 |
ICS/LABA | 2811 (46.52) | 1682 (63.74) | 235 (86.08) | 109 (95.61) | < 1e-15 |
LABA | 80 (1.32) | 65 (2.46) | 15 (5.49) | 10 (8.77) | 8.58e-14 |
LTRA | 1594 (26.38) | 1013 (38.39) | 177 (64.84) | 101 (88.6) | < 1e-15 |
OCS | 2604 (43.1) | 2639 (100) | 273 (100) | 114 (100) | < 1e-15 |
PDE-4 inhibitor | 3 (0.05) | 14 (0.53) | 2 (0.73) | 2 (1.75) | 1.51e-8 |
SABA | 5688 (94.14) | 2589 (98.11) | 272 (99.63) | 114 (100) | < 1e-15 |
SABA/anticholinergic | 295 (4.88) | 377 (14.29) | 80 (29.3) | 56 (49.12) | < 1e-15 |
Terbutaline | 31 (0.51) | 25 (0.95) | 11 (4.03) | 11 (9.65) | < 1e-15 |
Xanthine | 60 (0.99) | 81 (3.07) | 25 (9.16) | 17 (14.91) | < 1e-15 |