|
Medication Class
|
Number of Exacerbations
|
P-Value
|
|---|
|
0
|
1–2
|
3–4
|
5+
|
|---|
|
(N = 6042)
|
(N = 2639)
|
(N = 273)
|
(N = 114)
|
|---|
|
Anticholinergic
|
525 (8.69)
|
862 (32.66)
|
154 (56.41)
|
95 (83.33)
|
< 1e-15
|
|
Anti-IgE
|
20 (0.33)
|
29 (1.1)
|
12 (4.4)
|
10 (8.77)
|
<1e-15
|
|
Epinephrine
|
209 (3.46)
|
120 (4.55)
|
20 (7.33)
|
16 (14.04)
|
7.73e-9
|
|
ICS
|
2583 (42.75)
|
1307 (49.53)
|
170 (62.27)
|
72 (63.16)
|
< 1e-15
|
|
ICS/LABA
|
2811 (46.52)
|
1682 (63.74)
|
235 (86.08)
|
109 (95.61)
|
< 1e-15
|
|
LABA
|
80 (1.32)
|
65 (2.46)
|
15 (5.49)
|
10 (8.77)
|
8.58e-14
|
|
LTRA
|
1594 (26.38)
|
1013 (38.39)
|
177 (64.84)
|
101 (88.6)
|
< 1e-15
|
|
OCS
|
2604 (43.1)
|
2639 (100)
|
273 (100)
|
114 (100)
|
< 1e-15
|
|
PDE-4 inhibitor
|
3 (0.05)
|
14 (0.53)
|
2 (0.73)
|
2 (1.75)
|
1.51e-8
|
|
SABA
|
5688 (94.14)
|
2589 (98.11)
|
272 (99.63)
|
114 (100)
|
< 1e-15
|
|
SABA/anticholinergic
|
295 (4.88)
|
377 (14.29)
|
80 (29.3)
|
56 (49.12)
|
< 1e-15
|
|
Terbutaline
|
31 (0.51)
|
25 (0.95)
|
11 (4.03)
|
11 (9.65)
|
< 1e-15
|
|
Xanthine
|
60 (0.99)
|
81 (3.07)
|
25 (9.16)
|
17 (14.91)
|
< 1e-15
|
- ICS inhaled corticosteroid, LABA long-acting β2-agonist, LTRA leukotriene receptor antagonist, OCS oral corticosteroid, PDE-4 phosphodiesterase-4, SABA short-acting β2-agonist
