Table 1 The definition of uncontrolled asthma [5]

Uncontrolled asthma defined as at least one of the following:

1) Poor symptom control: ACQ consistently >1.5, ACT <20 (or “not well controlled” according NAEPP/GINA guidelines);

2) Frequent severe exacerbations: two or more bursts of systemic CS (>3 days each) in the previous year;

3) Serious exacerbations: at least one hospitalisation, ICU stay or mechanical ventilation in the previous year;

4) Airflow limitation: after appropriate bronchodilator withhold FEV1 < 80 % predicted (in the face of reduced FEV1/FVC defined as less than the lower limit of normal);

Controlled asthma that worsens on tapering of these high doses of ICS or systemic CS (or additional biologics)

*