Fig. 2

 A Serum C1M levels were increased in severe asthmatics (n = 86) compared to healthy controls (n = 41) and mild-moderate asthmatics (n = 106) compared to healthy controls (P = 0.0005, P = 0.0075), respectively. Data are presented as a Tukey box plot and analyzed using the Kruskal-Wallis test using Dunn’s multiple comparisons. Asterisks indicate statistically significance: **p < 0.01, ***p < 0.001. B Correlation between serum log-transformed C1M level and airway resistance at 5 Hz. Data were analysed using spearman’s correlation (r = 0.281, p > 0.0001)