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Table 2 Clinical characteristics, prognostic factors, and potential confounders of the study patients

From: Continuous versus intermittent short-acting β2-agonists nebulization as first-line therapy in hospitalized children with severe asthma exacerbation: a propensity score matching analysis

CharacteristicsOriginal cohortPropensity-matched cohort
Continuous nebulization
(n = 60)
Intermittent nebulization
(n = 129)
STDContinuous nebulization
(n = 56)
Intermittent nebulization
(n = 56)
STD
n(%)n(%)(%)n(%)n(%)(%)
Clinical characteristics
 Age (years), median (IQR)5.6(3.3,8.9)4.2(2.6,7.6)−34.15.6(3.3,8.7)5.6(3.2,8.6)−0.45
 Male gender37(61.7)84(65.1)7.1233(58.9)33(58.9)0
 Weight for age (%), median (IQR)23.6(6.7,73.1)28.4(3.9,75.5)2.8727(10.5,74.7)23(2.9,80.7)−2.87
Prognostic factors
 Obesity10(16.7)16(12.4)−12.0410(17.9)9(16.1)−4.72
 Not currently using controller medication22(36.7)59(45.7)18.3921(37.5)27(48.2)21.58
  ≥ 1 exacerbation in the past 12 months45(75.0)97(75.2)0.4542(75.0)41(73.2)−4.04
 History of endotracheal intubation7(11.7)12(9.3)−7.677(12.5)4(7.1)−17.91
 Exacerbation triggered by pneumonia18(30.0)50(38.8)18.4117(30.4)19(33.9)7.58
Treatment at emergency room
 Nebulized salbutamol < 3 doses8(13.3)25(19.4)16.318(14.3)12(21.4)18.56
 Terbutaline subcutaneous injection10(16.7)8(6.2)−33.119(16.1)4(7.1)−27.90
 Time to first dose of systemic corticosteroids (min), median (IQR)53(22,155)80(29,175)5.0953(23.5151)70(25,149.5)−11.40
Clinical data on initial admission
 Respiratory rate (per min), mean ± SD40.8±8.739.8±7.5−12.5040.7±8.140.5±8.0−1.78
 Pulse rate (per min), mean ± SD143.5±16.9147.2±16.722.04144.3±16.5143.6±16.4−4.12
 Oxygen saturation (%), mean ± SD93.93.293.5±3.4−11.4193.8±3.393.6±3.6−6.23
Co-medications during admission
 Ipratropium bromide nebulization25(41.7)37(28.7)−27.2723(41.1)17(30.4)−22.30
 Terbutaline subcutaneous injection31(51.7)15(11.6)−94.7028(50.0)7(12.5)−87.67
Propensity score, mean ± SD0.37±0.140.29±0.12−62.560.35±0.130.35±0.13−0.62
  1. Abbreviation: IQR Interquartile range; SD Standard deviation; STD Standardized difference