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Table 3 Treatment response in asthma patients with anti-IL 5/IL5R (reslizumab, mepolizumab or benralizumab) therapy and anti-IgE (omalizumab) therapy. Patients with discontinued biological therapy were included in the analyses

From: A comparison of biologicals in the treatment of adults with severe asthma – real-life experiences

 

Anti-IL5/IL5R (reslizumab, mepolizumab, benralizumab)

N = 42

 

Anti-IgE (omalizumab)

N = 22

 

Baseline

Change

P

Baseline

Change

P

Mean daily OCS dose (mg) a

7.07 (0–40. SD 7.13)

−3.00 (−35–25. SD 7.91)

0.020

4.82 (0–20. SD 6.50)

−2.29 (−20–0. SD 5.80)

0.085

Courses of OCS b

4.21 (0–12. SD 2.75)

−2.77 (−7.64–1. SD 2.81)

1.47 e−07

2.50 (0–6. SD 1.56)

−1.32 (−4–10. SD 2.01)

0.007

Courses of antibiotics b

1.40 (0–5. SD 1.42)

−0.69 (−5–7. SD 2.08)

0.040

0.95 (0–3. SD 0.93)

− 0.23 (− 3–5. SD 1.47)

0.488

Emergency room visits b

0.62 (0–8. SD 1.63)

−0.29 (−6–4. SD 1.30)

0.159

0.18 (0–1. SD 0.39)

0.18 (− 1–5. SD 1.19)

0.492

Hospitalisations b

0.52 (0–8. SD 1.42)

− 0.20 (−8–4. SD 1.63)

0.448

0.45 (0–2. SD 0.66)

0.00 (− 1–5. SD 1.21)

1.00

Sick leaves b

0.93 (0–6. SD 1.72)

− 0.58 (− 6–6. SD 1.86)

0.053

0.59 (0–4. SD 1.03)

−0.14 (− 3–11. SD 1.18)

0.602

Total number of exacerbation events c

7.57 (1–26. SD 5.59)

−4.43 (− 22–13. SD 6.24)

4.79 e− 05

4.68 (0–11. SD 3.40)

−1.50 (− 7–21. SD 5.55)

0.229

Blood eosinophil count (E9/litre)

0.45 (0.03–1.84. SD 0.37)

− 0.39 (− 1.79–0.01. SD 0.38)

2.36 e− 07

0.43 (0–1.34. SD 0.41)

−0.08 (− 0.61–0.52. SD 0.41)

0.433

Mean FEV1 (litres)

2.27 (1.0–4.2. SD 0.78)

0.17 (− 0.5–1.3. SD 0.41)

0.014

2.83 (1.5–4.2. SD 0.86)

0.05 (− 0.6–1.3. SD 0.54)

0.720

ACT (mean) d

15.63 (8–23. SD 4.28)

4.46 (− 15–13. SD 5.81)

0.0005

13.40 (7–22. SD 4.82)

8.50 (2–17. SD 5.63)

0.015

Exhaled nitric oxide (mean) (ppb)

28.17 (5–110. SD 28.98)

− 4.78 (− 68–40.1. SD 18.83)

0.759

35.66 (5–123. SD 36.30)

− 12.63 (− 71–21.5. SD 36.56)

0.592

Serum total IgE (mean) (kU/litre) e

290.85 (8–4672. SD 786.18)

160 (− 304–1693. SD 551.61)

0.424

313.36 (14–845. SD 248.76)

77.83 (− 24–369. SD 133.38)

0.249

  1. aOCS = per oral corticosteroid
  2. bNumber due to asthma during the last 12 months
  3. cdefined as the sum of courses of oral corticosteroid and antimicrobial drugs, sick leaves, hospitalisations and emergency room visits due to asthma during the last 12 months
  4. dACT = Asthma control test, maximal score 25 points
  5. eIn the hospital district that this study was conducted, serum total IgE is systematically measured before initiation of biological therapy but not during therapy. As a result, serum total IgE levels during therapy were available only occasionally and the change in the serum IgE level cannot be used as treatment effect measurement