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Table 4 Multivariable linear regression analysis of the association between 25(OH)D concentrations and measures of pulmonary function, asthma biomarkers, and asthma control

From: Associations between serum 25(OH)D concentrations and prevalent asthma among children living in communities with differing levels of urbanization: a cross-sectional study

  Overall (n = 884) Asthma (n = 413) Healthy controls (n = 471)
Unadjusted Beta (95% CI) Adjusteda Beta (95% CI) Unadjusted Beta (95% CI) Adjusted Beta (95% CI) Unadjusted Beta (95% CI) Adjusted Beta (95% CI)
Pre-bronchodilator FEV1 z-score −.129 (−0.750 to 0.493) .0566 (−0.560 to 0.673) 0.0298 (−0.672 to 0.731) 0.153 (−0.464 to 0.769) −0.484 (−1.56 to 0.592) −0.178 (−1.28 to 0.92)
p= 0.69 p= 0.86 p= 0.93 p= 0.63 p= 0.38 p= 0.75
Pre-bronchodilator FVC z-score −0.476 (−1.09 to 0.14) −0.256 (−0.868 to 0.356) −0.244 (−0.940 to 0.452) −0.155 (−0.782 to 0.472) −0.741 (−1.77 to 0.284) −0.455 (−1.52 to 0.607)
p= 0.13 p= 0.41 p= 0.49 p= 0.63 p= 0.16 p= 0.40
eNO (ppb) −.0306 (−.0610 to −0.000369) −0.0295 (−0.0621 to 0.00308) −0.0142 (−0.0440 to 0.0156) −0.0.00798 (−0.0359 to 0.00199) −0.0518 (−0.115 to 0.0113) −0.0711 (−0.139 to 0.0305)
p= 0.05 p= 0.08 p= 0.35 p= 0.57 p= 0.11 p= 0.04
Total serum IgE (kUa/L, log scale) 0.269 (−0.278 to 0.816) 0.0494 (−0.676 to 0.775) 0.305 (−0.392 to 1.00) −0.229 (−1.08 to 0.618) 0.401 (−0.466 to 1.27) 0.202 (−0.926 to 1.33)
p= 0.33 p= 0.89 p= 0.39 p= 0.60 p= 0.36 p= 0.73
ACT score NA NA −0.1477 (−0.420 to 0.126) −0.116 (−0.322 to 0.893) NA NA
p= 0.29 p= 0.27
  1. aAdjusted for season, age, sex, BMI, and SES. Overall model also adjusted for asthma status