Table 3 Sputum cell characteristics, CXC3R ligands, and IL-8 stratified by subjects’ sputum eosinophil and neutrophil percentages
From: CXC chemokine superfamily induced by Interferon-γ in asthma: a cross-sectional observational study
Paucigranulocytic | Eosinophil-predominant or Neutrophil-predominant | Mixed granulocytic | Healthy subjects | Overall | |
|---|---|---|---|---|---|
P value* | |||||
Subjects, n | 9 | 22 (Eos/Neu, 19/3 ) | 8 | 12 | |
Cell population in sputum | |||||
% Squamous | 30.5 (14.1) | 18.5 (11.8) | 12.2 (8.0) †, ‡ | 30.4 (11.3) | 0.002 |
% Mac | 40.2 (12.1) †, § | 28.9 (13.1) | 15.5 (8.0) | 19.6 (19.7) | 0.002 |
% Lym | 4.7 (4.2) | 9.7 (6.3) | 4.1 (2.6) | 6.3 (7.7) | N. S. |
% Neu | 23.7 (9.7) | 30.4 (17.6) | 57.1 (10.7) װ, ¶, # | 32.6 (26.9) | 0.003 |
% Eos | 1.0 (0.6) | 13.9 (14.5) ††, ‡‡ | 10.9 (11.5) | 0.5 (1.0) | 0.002 |
% Eos + % Neu | 24.6 (10.2) | 45.1 (19.0) †, ‡ | 68.1 (10.5)§§, װװ, ¶¶ | 21.6 (5.5) | <0.0001 |
CXC chemokine in sputum | |||||
IP-10 (pg/mL) | 31.2 (31.2–242.1) | 31.2 (31.2–156.6) | 221.5 (92.7–411.6) §§,¶¶ | 31.2 (31.2–31.2) | 0.002 |
Mig (pg/mL) | 588.1 (105.1–902.6) ## | 763.3 (62.5–1916.0) ## | 1938.1 (1121.1–2757.7) §§, ††† | 62.5 (62.5–62.5) | <0.0001 |
I-TAC (pg/mL) | 7.8 (7.8–26.6) | 7.8 (7.8–16.2) | 7.8 (7.8–244.3) | 7.8 (7.8–7.8) | N. S. |
IL-8 (Log, pg/mL) | 2336.4 (3.2, 697.1–3734.5) ‡‡‡ | 4079.4 (3.4, 957.7–4947.5) §§§ | 13305.5 (3.9, 1373.5–28075.2) §§§, װװװ | 622.0 (2.9, 276.3–1709.6) | 0.04 |