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Table 3 Sputum cell characteristics, CXC3R ligands, and IL-8 stratified by subjects’ sputum eosinophil and neutrophil percentages

From: CXC chemokine superfamily induced by Interferon-γ in asthma: a cross-sectional observational study

  Paucigranulocytic Eosinophil-predominant or Neutrophil-predominant Mixed granulocytic Healthy subjects Overall
P value*
Subjects, n 9 22 (Eos/Neu, 19/3 ) 8 12  
Cell population in sputum
 % Squamous 30.5 (14.1) 18.5 (11.8) 12.2 (8.0) †, ‡ 30.4 (11.3) 0.002
 % Mac 40.2 (12.1) †, § 28.9 (13.1) 15.5 (8.0) 19.6 (19.7) 0.002
 % Lym 4.7 (4.2) 9.7 (6.3) 4.1 (2.6) 6.3 (7.7) N. S.
 % Neu 23.7 (9.7) 30.4 (17.6) 57.1 (10.7) װ, ¶, # 32.6 (26.9) 0.003
 % Eos 1.0 (0.6) 13.9 (14.5) ††, ‡‡ 10.9 (11.5) 0.5 (1.0) 0.002
 % Eos + % Neu 24.6 (10.2) 45.1 (19.0) †, ‡ 68.1 (10.5)§§, װװ, ¶¶ 21.6 (5.5) <0.0001
CXC chemokine in sputum
 IP-10 (pg/mL) 31.2 (31.2–242.1) 31.2 (31.2–156.6) 221.5 (92.7–411.6) §§,¶¶ 31.2 (31.2–31.2) 0.002
 Mig (pg/mL) 588.1 (105.1–902.6) ## 763.3 (62.5–1916.0) ## 1938.1 (1121.1–2757.7) §§, ††† 62.5 (62.5–62.5) <0.0001
 I-TAC (pg/mL) 7.8 (7.8–26.6) 7.8 (7.8–16.2) 7.8 (7.8–244.3) 7.8 (7.8–7.8) N. S.
 IL-8 (Log, pg/mL) 2336.4 (3.2, 697.1–3734.5) ‡‡‡ 4079.4 (3.4, 957.7–4947.5) §§§ 13305.5 (3.9, 1373.5–28075.2) §§§, װװװ 622.0 (2.9, 276.3–1709.6) 0.04
  1. Data are presented as means (SD) unless otherwise indicated. Nonparametric data are shown as medians (25 to75 %)
  2. *P values are calculated with the Kruskal-Wallis test and the Mann–Whitney U test for nonparametric data and ANOVA for variables with a parametric distribution. Initial analyses with a significant difference are further explored by post hoc pairwise analyses (Bonferroni correction). Mac, Macrophages; Lym, Lymphocytes; Eos, eosinophils; Neu, neutrophils
  3. v. s. Healthy,† p = 0.01; װ p = 0.03; †† p = 0.006; §§ p < 0.0001; ## p = 0.04; ‡‡‡ p = 0.05; §§§ p = 0.002
  4. v. s. Pauci, ‡ p = 0.01; ¶ p = 0.003; ‡‡ p = 0.02; װװ p < 0.0001; ††† p = 0.008; װװװ p = 0.05
  5. v. s. Eosinophil-predominant or Neutrophil-predominant, # p = 0.006; ¶¶ p = 0.04
  6. v. s. Mixed, § p = 0.005