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Table 1 Characteristics of Subjects

From: CXC chemokine superfamily induced by Interferon-γ in asthma: a cross-sectional observational study

  Asthma patients Healthy subjects P value*
Subjects, n (%) 39 12  
Age, y 55 (20–72) 47 (30–57) 0.02
Male/female, n (Male, %) 16 (41)/23 4 (33)/9 0.05
BMI (kg/m2) 22.5 (3.8) 22.2 (3.1) N.S.
Duration of asthma (y) 6.5 (2–16.5) N. A. N. A.
Ex-smokers, n (%) 14 (36) 0 (0) 0.02
Medication
 ICS dose (μg/day) 995 (400–1300) N. A. N. A.
 Long acting β2-agonist, n (%) 27 (69) N. A. N. A.
 Leukotriene receptor antagonist, n (%) 27 (69) N. A. N. A.
 Oral corticosteroids, n (%) 8 (21) N. A. N. A.
Atopy, n (%) 25 (64) 5 (42) N.S.
Asthma control and health care use, past year
 β-agonist use/day 0.00 (0.00–0.03) N. A. N. A.
 Oral corticosteroid bursts 1.0 (0.0–2.0) N. A. N. A.
FEV1, L/min 2.0 (0.4) 3.2 (0.8) <0.0001
FEV1, % predicted 80.4 (20.3) 105.5 (14.6) <0.0001
FeNO, ppb 29.5 (14.0–45.5) N.D. N. A.
Cell population in sputum
 % Squamous 16.7 (7.6–25.2) 32.9 (25.1–42.4) 0.03
 % Macrophage 26.0 (19.0–43.1) 37.5 (27.6–4 3.2) N. S.
 % Lymphocyte 7.3 (4.6–11.9) 7.5 (3.7–13.4) N. S.
 % Neutrophil 29.9 (24.1–51.2) 21.6 (18.6–24.1) N. S.
 % Eosinophil 6.4 (1.6–11.4) 0.5 (0.0–2.0) <0.0001
 % Eosinophil 38.3 (29.8–63.1) 23.9 (18.6–24.8) 0.002
  + % Neutrophil
CXC chemokine in sputum
 IP-10 (pg/mL) 60.1 (31.2–306.7) 31.2 (0.0) 0.01
 Mig (pg/mL) 989.5 (62.5–2698.2) 62.5 (0.0) <0.0001
 I-TAC (pg/mL) 7.8 (7.8–24.3) 7.8 (0.0) N. S.
 IL-8 ( Log, pg/mL) 3120.3 (3.5, 1442.9 - 9115.1) 1356.6 (3.0, 522.6 - 2550.4) 0.01
  1. Data are presented as means (SD) unless otherwise indicated. Nonparametric data are shown as medians (25 to 75 %). Age is shown as mean (minimum to maximum)
  2. ICS = inhalation corticosteroid (beclomethasone), where 1 μg beclomethasone = 1 μg budesonide = 0.5 μg fluticasone
  3. *P values are calculated with the use of the Mann–Whitney U test for nonparametric data, Student’s t-test for variables with a parametric distribution, and Fisher’s exact test for comparison of proportions
  4. N. A.; not applicable. N.D.: not done