Study (year) | Study design | Ages | Prevalence of AHR | Clinical Correlates of AHR |
---|---|---|---|---|
Leong et al. (1997) [34] | Cold air challenge in 32 children with SCD | 6–19 years | 67 % with 10 % drop in FEV1 | No difference in prevalence of AHR to cold air between SCD patients with and without asthma; |
Sylvester et al. (2007) [33] | Cold air challenge in 42 children with HbSS | 6–16 years | 14 % with 10 % drop in FEV1 | No association between prior history of ACS and likelihood of having a positive cold air challenge test |
Strunk et al. (2008) [35] | MCT in 21 clinically referred children with SCD and respiratory symptoms | 5–18 years | 67 % with PC20 < 12.5 mg/ml | Not evaluated |
Ozbek et al. (2007) [36] | MCT in 31 children | 6–16 years | 77 % with PC20 < 16 mg/ml, 58 % with PC20 < 1 mg/ml | No differences in PC20 between those with and without history of ACS (p = 0.06) |
Field et al. (2011) [40] | MCT in 99 children with HbSS or HbSβ0 |  | 55 % with PC20 < 4 mg/ml | Methacholine DRS not associated with STR, BDR, peripheral blood eosinophil count, or asthma diagnosis; DRS was associated with serum IgE and LDH |
Chaudry et al. (2014) [41] | Cohort study 50 children with SCD and 50 non-SCD controls, 93 completed MCT | 10–18 years | Prevalence of PC20 below a specified threshold not reported; | No difference in DRS between those DRS higher in children with asthma in both groups; No differences in DRS between HbSS and HbSC; DRS not associated with FEV1, FEV1/FVC, FeNO, or IGE among the SCD group; |
Vendramini et al. (2006) [37] | MCT in 26 adults with and 28 controls without SCD | 18–41 years | PC20 < 16 mg/ml in 31 % of SCD, 7 % of controls | Positive methacholine challenge not associated with having a baseline obstructive pattern on spirometry |
Sen et al. (2009) [38] | MCT in 31 adults with SCD | 18–44 years | 48 % with PC20 < 16 mg/ml, 42 % with PC20 < 4 mg/ml | Significant association between the number of retrospective ACS events and having a positive methacholine challenge |