Table 1 Summary of studies reporting prevalence of asthma in SCD patients
Study (year) | Study design | SCD type | Ages | How defined | Prevalence (%) |
|---|---|---|---|---|---|
Boyd et al. (2006) [5] | CSSCD: 291 children enrolled in prospective cohort study | HbSS | Enrolled <6 months and followed through >5 years | Parent report of physician diagnosis of asthma | 17 % |
Rosen et al. (2014) [11] | SAC: 243 children in a prospective cohort study | HbSS or HbSβ0 | 4–19 years | Physician diagnosis of asthma and use of asthma medication ever, via parent report and confirmed with chart review [3] | 28 % |
Knight-Madden et al. (2005) [6] | Case control study of 80 children with SCD from Jamaica with 80 age, ethnic matched controls | HbSS | 5–10 years | Parent report using modified ISAAC questionnaire (“touch of asthma”) for “lifetime asthma;” and wheeze or cough in past 12 months lasting 7 days in absence of URI for “current asthma” | 48 % asthma ever, 41 % current asthma |
Paul et al. (2013) [13] | PUSH: 503 children with SCD in a prospective cohort study | All types | 3–20 years | Parent answers yes to question “medical history of asthma or wheezing” [17] | 24 % |
Cohen et al. (2011) [21] | 114 adults with SCD in a prospective cohort study | All types | 18–72 years | Positive response to the ATS-DLD question “Has a doctor ever diagnosed you with asthma” plus use of a controller medication | 30 % |